SYNTHESIS AND PROPERTIES OF SOME XANTHINE DERIVATIVES

Authors

  • Gennadij Kalayanov  Physicochemical Institute named after A.V. Bogatsky of the National Academy of Sciences of Ukraine http://orcid.org/
  • Eduard Ivanov  Physicochemical Institute named after A.V. Bogatsky of the National Academy of Sciences of Ukraine http://orcid.org/
  • Roksana Ivanova Odessa National Maritime University http://orcid.org/

DOI:

https://doi.org/10.30888/2415-7538.2020-16-01-036

Keywords:

xanthines, cyclohomologues of xanthines, 1, 4-diasepines

Abstract

Reasearch and development of new methods of synthesis of organic compaunds is one of the most important tasks of modern organic chemistry.The possibility of a new approach to the synthesis of cyclohomologists of caffeine, theophylline and theobromine was

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References

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Nawoiski A. Benzodiazepiny skondensowane z pirscieniami heterocyclikicznymi // Wiad. Chtm. - 1977. - t. 34. - № 12. - s. 753-768.

Annelated 1,5- benzodiazepines. Part 1. Three , four and fife hembered Ringes / A. Chimirci, R. Gitto, S. Grasso et al // Heterocycles. - 1993. - V. 36. - № 3. -P. 601-637.

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Богатский А.В., Андронати С.А. / Современное состояние химии 1,4-диазепинов // Успехи химии. - 1970. - Т. 39. - С. 2217-2255.

Богатский А.В., Иванов Э.И., Синтез 1,4,7- триметил-4,5,7,8-тетрагидроимидазо[4,5-е][1,4]-диазепин-5,8(6Н)-диона - циклического гомолога кофеина // Украинский химический журнал. - 1980. - Т. 46. - № 10. - С. 1074-1075.

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Synthesis of imidazo[4,5-e][1,4]diazepine and imidazo[4,5-e][1,4]oxazepine Derivatives using Caffeidine, a Hydrolysis Product of Coffeine / T. Ohsaki, T. Kuviki et al // Chem. and Pharm. Bull. - 1986. - V. 34. - №9p — P. 3573-3587.

Bridson P.K., Weirich T.P. Cyclic Homologs of Xanthines. Imidazo[4,5-e][1,4]diazepine-5,8-diones // J. Heterocyclic. Chem. - 1988. - V. 25. - P. 1179-1182.

Daly J.W., Hide I., Bridson P.K. Imidazodiazepines. A new class of adenosine receptor antagonists // J. Med. Chem. - 1990. - V. 33. - № 10. - P. 2818-2821.

Tozo Fujii, Tohru Saito, Tetsunori Fujisama. Alternative Synthesis of azepinomycin // Heterocecles. - 1988. - V. 27. - № 5. - 1163-1166.

Synthesis of azepinomycin and its β-D-ribofuranoside / K. Isshiki, Y. Takahashi et al // J. Antibiot. - 1987. - V. - 40. - № 10. - P. 1461-1463.

Bridson P.K. Synthesis of Deoxyazepinomycin // Heterocecles. - 1994. - V. 38. - № 5. - 1007-1014.

Hosmane R.S., Bhan A., Karpel R.L. The Synthesis and Biological Investigations of Novel Ring-Espanded Nucleosides and Homopolymers Containing the 5:7 Fused Heterocyclic Ring System Imidazo[4,5-c][1,4]diazepine // J. Org. Chem. - 1990.-.V. 55. - P. 5882-5890.

Hosmane R.S., Bhan A. The Synthesis of Ring-Espanded of Xanthine Containing Imidazo[4,5-e][1,4]diazepine Ring System // J. Heterocyclic. Chem. - 1990. - V. 27. - P. 2189-2196.

Hosmane R.S., Bhan A. Reactions of Ring-Espanded of Xanthines // J. Heterocyclic. Chem. - 1993. - V. 30. - P. 1453-1462.

Синтез гомологов теофиллина и теобромина /Э.И. Иванов, И.М. Ярощенко, Г.Д. Калаянов // Химия гетероциклических соединений. -1989. - № 12. - С. 1699.

Синтез гомологов природных алколоидов теофиллина и теобромина Э.И. Иванов, И.М. Ярощенко, Г.Д. Калаянов // Украинский химический журнал. - 1990. - Т. 56. - № 12. - С. 1316-1318.

References:

Schulze E. 1,4- und 1,5-Benzodiazepine mit kondensierten Heterocyclen // Deutsche Apotheker Zeitung.-1975.- B. 115 - № 34. - S. 1253-1262.

Nawoiski A. Benzodiazepiny skondensowane z pirscieniami heterocyclikicznymi // Wiad. Chtm. - 1977. - t. 34. - № 12. - s. 753-768.

Annelated 1,5- benzodiazepines. Part 1. Three , four and fife hembered Ringes / A. Chimirci, R. Gitto, S. Grasso et al // Heterocycles. - 1993. - V. 36. - № 3. -P. 601-637.

Recent Advances in the Synthesis of annelated 1,4- benzodiazepines / M.Chulam, R.Podala, A. Khalil et al // Heterocycles. - 1986. - V. 24. - № 12. -P. 3489-3530.

Bogatsky A.V., Andronati S.A. Current status of chemistry of 1,4-diasepine // Chemistry progress.- 1970.- V. 39. - P. 2217-2255.

Bogatsky A.V., Ivanov E.I. Synthesis of 1,4,7-trimethyl-4,5,7,8-tetrahydro-(6H)-imidazo[4,5-e][1,4]-diazepine-5,8- dion - cyclic homolog of coffeine // Ukrainian journal of Chemistry — 1980. - V. 46 - № 10. - P. 1074-1075.

Ivanov E.I., Bogatsky A.V., Zakharov K.S. Synthesis and Properties of derivatives of 1,4,7-trimethyl-4,5,7,8-tetrahydro-(6H)-imidazo[4,5-e][1,4]diazepine-5,8- dion // Reports of Academy of Sciences of the USSR. -1980. - V. 255. № 3. - P. 591-593.

Synthesis of imidazo[4,5-e][1,4]diazepine and imidazo[4,5-e][1,4]oxazepine Derivatives using Caffeidine, a Hydrolysis Product of Coffeine / T. Ohsaki, T. Kuviki et al // Chem. and Pharm. Bull. - 1986. - V. 34. - №9p — P. 3573-3587.

Bridson P.K., Weirich T.P. Cyclic Homologs of Xanthines. Imidazo[4,5-e][1,4]diazepine-5,8-diones // J. Heterocyclic. Chem. - 1988. - V. 25. - P. 1179-1182.

Daly J.W., Hide I., Bridson P.K. Imidazodiazepines. A new class of adenosine receptor antagonists // J. Med. Chem. - 1990. - V. 33. - № 10. - P. 2818-2821.

Tozo Fujii, Tohru Saito, Tetsunori Fujisama. Alternative Synthesis of azepinomycin // Heterocecles. - 1988. - V. 27. - № 5. - 1163-1166.

Synthesis of azepinomycin and its β-D-ribofuranoside / K. Isshiki, Y. Takahashi et al // J. Antibiot. - 1987. - V. - 40. - № 10. - P. 1461-1463.

Bridson P.K. Synthesis of Deoxyazepinomycin // Heterocecles. - 1994. - V. 38. - № 5. - 1007-1014.

Hosmane R.S., Bhan A., Karpel R.L. The Synthesis and Biological Investigations of Novel Ring-Espanded Nucleosides and Homopolymers Containing the 5:7 Fused Heterocyclic Ring System Imidazo[4,5-c][1,4]diazepine // J. Org. Chem. - 1990.-.V. 55. - P. 5882-5890.

Hosmane R.S., Bhan A. The Synthesis of Ring-Espanded of Xanthine Containing Imidazo[4,5-e][1,4]diazepine Ring System // J. Heterocyclic. Chem. - 1990. - V. 27. - P. 2189-2196.

Hosmane R.S., Bhan A. Reactions of Ring-Espanded of Xanthines // J. Heterocyclic. Chem. - 1993. - V. 30. - P. 1453-1462.

Synthesis of Homologs of theophylline and theobromine / E.I. Ivanov., I.M. Yaroschenko, G.D. Kalayanov // Chemistry of heterocyclic compounds. - 1989. - №12. - P. 1699.

Synthesis of Homologs of natural alkoloids of theophylline and theobromine / E.I. Ivanov., I.M. Yaroschenko, G.D. Kalayanov // Ukrainian journal of Chemistry — 1990. - V. 56 - № 12. - P. 1316-1318.

Published

2020-02-29

How to Cite

Калаянов, Г., Иванов, Э., & Иванова, Р. (2020). SYNTHESIS AND PROPERTIES OF SOME XANTHINE DERIVATIVES. Scientific Look into the Future, 1(16-01), 53–59. https://doi.org/10.30888/2415-7538.2020-16-01-036

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